来自欧洲红豆杉细胞培养物的新型生物活性紫杉烷类化合物。

New bioactive taxoids from cell cultures of Taxus baccata.

作者信息

Ma W, Park G L, Gomez G A, Nieder M H, Adams T L, Aynsley J S, Sahai O P, Smith R J, Stahlhut R W, Hylands P J

机构信息

PHYTOpharmaceuticals, Inc., San Carlos, California 94070.

出版信息

J Nat Prod. 1994 Jan;57(1):116-22. doi: 10.1021/np50103a016.

DOI:10.1021/np50103a016

PMID:7908950

Abstract

Four new taxoids were isolated from cell cultures of Taxus baccata. Their structures were elucidated by spectroscopic analyses. Two were the aglycones corresponding to previously isolated 7-O-xylosides of taxol C [1] and 10-deacetyltaxol C [2]. The third [3] had an N-methylated side-chain, while the fourth, named taxcultine [4], contained an n-propyl group on the side-chain. All four compounds actively promoted tubulin assembly. Taxol C [1] showed potent and selective cytotoxicity in the NCI human cell line screen.

摘要

从欧洲红豆杉的细胞培养物中分离出了四种新的紫杉烷类化合物。通过光谱分析阐明了它们的结构。其中两种是与先前分离出的紫杉醇C [1]和10-脱乙酰紫杉醇C [2]的7-O-木糖苷相对应的苷元。第三种[3]具有N-甲基化侧链，而第四种，命名为紫杉培汀[4]，在侧链上含有一个正丙基。所有这四种化合物均能积极促进微管蛋白组装。紫杉醇C [1]在NCI人类细胞系筛选中表现出强效且选择性的细胞毒性。