Brown N J, Rumsey R D, Read N W
Department of Biomedical Science, University of Sheffield, UK.
J Pharm Pharmacol. 1993 Dec;45(12):1033-6. doi: 10.1111/j.2042-7158.1993.tb07175.x.
Studies were carried out on 28 male adult rats to investigate whether the selective cholecystokinin-receptor antagonist devazepide influences gastrointestinal transit under control conditions and when it is delayed by ileal infusion of lipid. Stomach-to-caecum transit time of the head of the test meal was measured using environmental hydrogen analysis and the distribution of the meal was assessed using the radiolabelled meal technique. Oral administration of devazepide (4 mg kg-1) had no significant effect on transit time of the head of the baked bean test meal under control conditions, but significantly reversed the delay in transit time induced by ileal infusion of lipid (P < 0.01). Studying the distribution of the meal showed that Intralipid delayed transit time by delaying both gastric emptying (P < 0.01) and small bowel transit (P < 0.05). Devazepide did not alter the control distribution of the meal during ileal saline infusion, but during ileal infusion of lipid, devazepide further delayed gastric emptying (P < 0.01); the geometric centre of the meal was situated more proximally in the gastrointestinal tract (P < 0.05), but there was more of the meal in the colon (P < 0.01). The latter is compatible with the early rise in environmental hydrogen during devazepide administration and ileal lipid infusion and suggests that peripheral cholecystokinin receptors may modulate or mediate the delay in small bowel transit induced by ileal lipid. However, the data also suggest that mechanisms other than those involving cholecystokinin play a dominant role in the regulation of postprandial and lipid-delayed gastric emptying of a meal.
对28只成年雄性大鼠进行了研究，以调查选择性胆囊收缩素受体拮抗剂地伐西匹在对照条件下以及在回肠输注脂质导致胃肠运输延迟时是否会影响胃肠运输。使用环境氢气分析测量试验餐头部从胃到盲肠的运输时间，并使用放射性标记餐技术评估餐的分布。在对照条件下，口服地伐西匹（4毫克/千克）对烤豆试验餐头部的运输时间没有显著影响，但显著逆转了回肠输注脂质引起的运输时间延迟（P<0.01）。对餐分布的研究表明，英脱利匹特通过延迟胃排空（P<0.01）和小肠运输（P<0.05）来延迟运输时间。在回肠输注生理盐水期间，地伐西匹没有改变餐的对照分布，但在回肠输注脂质期间，地伐西匹进一步延迟了胃排空（P<0.01）；餐的几何中心位于胃肠道更近端（P<0.05），但结肠中的餐更多（P<0.01）。后者与地伐西匹给药和回肠脂质输注期间环境氢气的早期升高一致，并表明外周胆囊收缩素受体可能调节或介导回肠脂质引起的小肠运输延迟。然而，数据还表明，除了涉及胆囊收缩素的机制外，其他机制在餐后和脂质延迟的餐胃排空调节中起主导作用。
