Mulder D W, Nunn A J, Kamali A, Nakiyingi J, Wagner H U, Kengeya-Kayondo J F
MRC (UK)/ODA/UVRI Programme on AIDS in Uganda, Entebbe.
Lancet. 1994 Apr 23;343(8904):1021-3. doi: 10.1016/s0140-6736(94)90133-3.
The mortality in 15 villages in South-West Uganda was studied in relation to HIV infection. After a population census, serum samples were tested for antibodies to HIV-1. Deaths were ascertained over 2 years. Unequivocal HIV-1 serology results were available for 9389 individuals. The prevalence of infection was 4.8% for all ages and 8.2% for adults (aged 13 or more). 198 deaths were recorded during 15,725 person years of observation. Mortality among seronegative adults was 7.7 per 1000 and among seropositive adults 115.9 per 1000. The excess annual death rate associated with HIV-1 infection was 5.3 per 1000 and in adults 7.9 per 1000. Highest excess mortality was 16.9 per 1000 in the age group 25-34. Among adults, half of all deaths and among those aged 13-44 over 80% of deaths were attributable to HIV-1 infection. These results show the strong impact that HIV-1 infection is having on mortality in a rural area of Uganda where the overall HIV-1 adult prevalence rate is below 10%--a rate lower than in many other parts of East Africa.
对乌干达西南部15个村庄的死亡率与艾滋病毒感染的关系进行了研究。在进行人口普查后，检测血清样本中的HIV-1抗体。在两年时间里确定死亡情况。9389人的HIV-1血清学检测结果明确。所有年龄段的感染率为4.8%，成年人（13岁及以上）的感染率为8.2%。在15725人年的观察期内记录了198例死亡。血清阴性成年人的死亡率为每1000人中有7.7例，血清阳性成年人的死亡率为每1000人中有115.9例。与HIV-1感染相关的年超额死亡率为每1000人中有5.3例，成年人中为每1000人中有7.9例。25 - 34岁年龄组的最高超额死亡率为每1000人中有16.9例。在成年人中，所有死亡人数的一半以及13 - 44岁人群中超过80%的死亡归因于HIV-1感染。这些结果表明，在乌干达一个农村地区，HIV-1感染对死亡率产生了强烈影响，该地区HIV-1成年人总体患病率低于10%，这一比例低于东非许多其他地区。
