Krivosheev B N, Krivosheev A B
Ter Arkh. 1994;66(2):32-6.
Urinary and fecal levels of porphyrins were measured spectrophotometrically for 388 patients. 66 of them suffered from melanodermic skin lesions without hepatic affection, 95 had chronic hepatic diseases and 227 exhibited porphyria cutanea tarda. The results were considered in relation to the lesion and alcohol habits. Alcohol proved to provoke manifestations of porphyrin disbolism. High protoporphyrin fecal concentrations serve early indications of alcohol-induced damage to the liver. Alcohol abuse results in persistent disorders of porphyrin metabolism in subjects with chronic active hepatitis and hepatic cirrhosis. In established clinical and biochemical syndrome of porphyria cutanea tarda alcohol contributes to further progression of fermentopathy specific for relevant porphyria.
采用分光光度法对388例患者的尿液和粪便中的卟啉水平进行了测量。其中66例患有无肝脏病变的黑皮病性皮肤损害，95例患有慢性肝病，227例表现为迟发性皮肤卟啉症。结合病变情况和饮酒习惯对结果进行了分析。结果表明，酒精可引发卟啉代谢异常。粪便中原卟啉浓度升高是酒精性肝损伤的早期指标。酒精滥用会导致慢性活动性肝炎和肝硬化患者卟啉代谢持续紊乱。在已确诊的迟发性皮肤卟啉症临床和生化综合征中，酒精会促使相关卟啉症特有的发酵病进一步发展。
