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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Adv Prostaglandin Thromboxane Res. 1976;2:791-801.

Nonsteroid antiinflammatory drugs inhibit prostaglandin biosynthesis in concentrations likely to be found in body fluids during therapy. The assembled evidence, together with the actions of prostaglandins, overwhelmingly supports the theory that this antienzyme effect is the mechanism of action of aspirin-like drugs. 2. Intermediates in prostaglandin biosynthesis and their nonprostaglandin derivatives such as RCS (thromboxane A2) may also play a part in the inflammatory process. 3. There is a close interplay between bradykinin and prostaglandins, not only in inflammation, but also in other systems. 4. Bradykinin stimulates phospholipase A2, thereby making available prostaglandin precursors.

非甾体抗炎药在治疗期间体液中可能存在的浓度下抑制前列腺素生物合成。综合证据以及前列腺素的作用，有力地支持了这种抗酶作用是阿司匹林类药物作用机制的理论。2. 前列腺素生物合成中的中间体及其非前列腺素衍生物，如RCS（血栓素A2），也可能在炎症过程中起作用。3. 缓激肽与前列腺素之间存在密切的相互作用，不仅在炎症中如此，在其他系统中也是如此。4. 缓激肽刺激磷脂酶A2，从而使前列腺素前体得以利用。

Adv Prostaglandin Thromboxane Res. 1976;2:791-801.

Nonsteroid antiinflammatory drugs inhibit prostaglandin biosynthesis in concentrations likely to be found in body fluids during therapy. The assembled evidence, together with the actions of prostaglandins, overwhelmingly supports the theory that this antienzyme effect is the mechanism of action of aspirin-like drugs. 2. Intermediates in prostaglandin biosynthesis and their nonprostaglandin derivatives such as RCS (thromboxane A2) may also play a part in the inflammatory process. 3. There is a close interplay between bradykinin and prostaglandins, not only in inflammation, but also in other systems. 4. Bradykinin stimulates phospholipase A2, thereby making available prostaglandin precursors.

非甾体抗炎药在治疗期间体液中可能存在的浓度下抑制前列腺素生物合成。综合证据以及前列腺素的作用，有力地支持了这种抗酶作用是阿司匹林类药物作用机制的理论。2. 前列腺素生物合成中的中间体及其非前列腺素衍生物，如RCS（血栓素A2），也可能在炎症过程中起作用。3. 缓激肽与前列腺素之间存在密切的相互作用，不仅在炎症中如此，在其他系统中也是如此。4. 缓激肽刺激磷脂酶A2，从而使前列腺素前体得以利用。