Takahashi S, Mikami T, Watanabe Y, Okazaki M, Okazaki Y, Okazaki A, Sato T, Asaishi K, Hirata K, Narimatsu E
Division of Pathology, Sapporo Medical University Hospital, Japan.
Am J Clin Pathol. 1994 Apr;101(4):519-25. doi: 10.1093/ajcp/101.4.519.
The authors studied the role of 70-Kd heat shock protein (HSP70) in the progression of breast cancer by examining the correlation between the expression of HSP70 and epidermal growth factor receptor, c-erbB-2, p53, and estrogen receptor in 124 cases of invasive primary human breast cancers. Positivity of an anti-HSP70 monoclonal antibody, C92, was closely associated with the elevation of estrogen receptor (P < .008), whereas it inversely correlated with the expression of p53 (P < .01). In addition, the expression of HSP70 correlated inversely with the expression of epidermal growth factor receptor, although the correlation was not statistically significant (P = .06). These results suggest that the expression of HSP70 plays a role in the progression of human breast cancer.
作者通过检测124例原发性浸润性人类乳腺癌中70-Kd热休克蛋白（HSP70）的表达与表皮生长因子受体、c-erbB-2、p53和雌激素受体之间的相关性，研究了HSP70在乳腺癌进展中的作用。抗HSP70单克隆抗体C92的阳性与雌激素受体升高密切相关（P < 0.008），而与p53的表达呈负相关（P < 0.01）。此外，HSP70的表达与表皮生长因子受体的表达呈负相关，尽管相关性无统计学意义（P = 0.06）。这些结果表明，HSP70的表达在人类乳腺癌进展中起作用。
