Disciplina de Ginecologia, Departamento de Obstetrícia E Ginecologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Sci Rep. 2022 Jul 29;12(1):13012. doi: 10.1038/s41598-022-17414-6.
The early diagnosis of breast cancer can improve treatment and prognosis. We sought to evaluate whether the serum concentration of the 70 kDa heat shock protein (HSPA1A) was elevated in Brazilian women with breast cancer, and if levels correlated with tumor characteristics. This was a cross-sectional, analytical, case-control exploratory study performed at The University of São Paulo School of Medicine. From September 2017 to December 2018, 68 women with breast cancer and 59 controls were recruited. The HSPA1A concentration in serum samples was determined by ELISA by individuals blinded to the clinical data. The mean ages in the study and control groups were 54.9 and 52.0 years, respectively. The median serum levels of HSPA1A were elevated in women with breast cancer (1037 pg/ml) compared with controls (300 pg/ml) (p < 0.001). Elevated HSPA1A levels were associated with advanced histological tumor grade (p < 0.001) and with the cell proliferation index (KI67) (p = 0.0418). The HSPA1A concentration was similar in women with different histological subtypes, nuclear grade, hormone receptor expression, HER2 status and the presence or absence of angiolymphatic invasion. Elevated serum HSPA1A in Brazilian women with advanced histological grade and proliferation index breast cancer supports the potential value of additional investigation on larger and more varied populations to verify the value of HSPA1A detection as a component of breast cancer diagnosis and progression.
早期诊断乳腺癌可以改善治疗效果和预后。我们试图评估巴西乳腺癌女性血清中 70kDa 热休克蛋白（HSPA1A）的浓度是否升高，以及其水平是否与肿瘤特征相关。这是一项在圣保罗大学医学院进行的横断面、分析性、病例对照探索性研究。从 2017 年 9 月至 2018 年 12 月，共招募了 68 名乳腺癌女性和 59 名对照者。通过 ELISA 法由对临床数据不知情的个体来确定血清样本中的 HSPA1A 浓度。研究组和对照组的平均年龄分别为 54.9 岁和 52.0 岁。与对照组（300pg/ml）相比，乳腺癌女性（1037pg/ml）的血清 HSPA1A 中位水平升高（p<0.001）。高水平的 HSPA1A 与组织学肿瘤分级较高（p<0.001）和细胞增殖指数（KI67）相关（p=0.0418）。不同组织学亚型、核分级、激素受体表达、HER2 状态以及是否存在血管淋巴管侵犯的女性之间，HSPA1A 浓度相似。在组织学分级和增殖指数较高的巴西乳腺癌女性中，血清 HSPA1A 升高，支持在更大、更多样化的人群中进一步研究的潜在价值，以验证 HSPA1A 检测作为乳腺癌诊断和进展的一个组成部分的价值。
