Henn R M, Selcon S, Sturdevant R A, Isenberg J I, Grossman M I
Am J Dig Dis. 1976 Nov;21(11):921-5. doi: 10.1007/BF01071902.
Hospitalized male patients with endoscopically verified duodenal ulcer were studied to determine the effect of secretin on the clinical course of their disease. Seven patients received synthetic porcine secretin, 333 mug subcutaneously every 4 hr for 10 days, and 6 patients received placebo injections on the same schedule. Repeat endoscopy was performed within 48 hr of completing the 10-day treatment period. The trial was discontinued because of transient, asymptomatic, hyperamylasemia in secretin-treated patients. Although significant gastric alkalinization could be reproducibly demonstrated in secretin-treated patients, secretin was not more effective than placebo in relieving pain or healing duodenal ulcer. However, because the number of patients was small, definitive conclusions regarding efficacy of secretin in ulcer treatment could not be drawn.
对经内镜检查确诊为十二指肠溃疡的住院男性患者进行了研究，以确定促胰液素对其疾病临床病程的影响。7例患者接受合成猪促胰液素治疗，每4小时皮下注射333微克，共10天；6例患者按相同疗程接受安慰剂注射。在完成10天治疗期后的48小时内进行重复内镜检查。由于接受促胰液素治疗的患者出现短暂、无症状的高淀粉酶血症，该试验提前终止。尽管在接受促胰液素治疗的患者中可重复性地显示出显著的胃碱化，但促胰液素在缓解疼痛或治愈十二指肠溃疡方面并不比安慰剂更有效。然而，由于患者数量较少，无法就促胰液素在溃疡治疗中的疗效得出明确结论。
