Hortin G L, Landt M, Powderly W G
Department of Pathology, University of Alabama at Birmingham 35233.
Clin Chem. 1994 May;40(5):785-9.
Plasma concentrations of 21 amino acids were determined for 20 control subjects and 20 subjects infected with human immunodeficiency virus type 1 (HIV). Compared with the control subjects, the HIV-infected group had lower cystine, tryptophan, and methionine (decreased 67%, 52%, and 32%, respectively, P < 0.001 for each) and increased taurine (230%, P < 0.001) and lysine concentrations (30%, P < 0.001). Other amino acid concentrations changed modestly. Amounts of cystine, tryptophan, methionine, taurine, and lysine did not differ significantly between subgroups of HIV-infected subjects with > 200 (n = 6) or < 200 (n = 14) CD4+ lymphocytes per microliter, suggesting that the concentrations decrease soon after infection and change little thereafter. Activation of metabolism of cystine to taurine may explain reciprocal changes in these amino acids and known depletion of cystine and glutathione. The selective changes in amino acid profiles observed during HIV infection differ from those recognized for malnutrition or other pathological processes.
测定了20名对照受试者和20名感染1型人类免疫缺陷病毒（HIV）的受试者的21种氨基酸的血浆浓度。与对照受试者相比，HIV感染组的胱氨酸、色氨酸和蛋氨酸含量较低（分别降低了67%、52%和32%，每种情况P<0.001），而牛磺酸（升高230%，P<0.001）和赖氨酸浓度升高（30%，P<0.001）。其他氨基酸浓度变化不大。每微升CD4+淋巴细胞>200（n = 6）或<200（n = 14）的HIV感染受试者亚组之间，胱氨酸、色氨酸、蛋氨酸、牛磺酸和赖氨酸的含量没有显著差异，这表明这些浓度在感染后很快下降，此后变化很小。胱氨酸代谢为牛磺酸的激活可能解释了这些氨基酸的相互变化以及已知的胱氨酸和谷胱甘肽耗竭。HIV感染期间观察到的氨基酸谱的选择性变化不同于营养不良或其他病理过程中所认识到的变化。
