石蜡包埋切片中金颗粒的橙红色双折射：对金沉着病诊断的辅助手段

Orange-red birefringence of gold particles in paraffin wax embedded sections: an aid to the diagnosis of chrysiasis.

作者信息

al-Talib R K, Wright D H, Theaker J M

机构信息

Department of Pathology, Southampton University Hospitals, UK.

出版信息

Histopathology. 1994 Feb;24(2):176-8. doi: 10.1111/j.1365-2559.1994.tb01300.x.

DOI:10.1111/j.1365-2559.1994.tb01300.x

PMID:7910148

Abstract

Chrysiasis, the systemic deposition of gold pigment in patients on long term chrysotherapy, is identified histologically as small black granules within macrophages. Histological sections from 12 confirmed cases of chrysiasis were examined under crossed polarized light. This revealed a striking orange-red birefringence of the pigment not detected in other histologically similar deposits. This technique provides a valuable adjunct to the histological identification of gold without the need to resort to ultrastructural and analytical procedures.

摘要

金质沉着症是长期接受金疗法的患者体内金色素的全身性沉积，在组织学上表现为巨噬细胞内的小黑颗粒。对12例确诊的金质沉着症病例的组织切片在交叉偏振光下进行检查。结果显示该色素呈现出明显的橙红色双折射，这在其他组织学上类似的沉积物中未被检测到。这项技术为金的组织学鉴定提供了有价值的辅助手段，无需借助超微结构和分析程序。