Tatsumi K, Hirai K, Fukushima T, Einaga T, Furuya H, Okuda T
Department of Anesthesiology, Nara Medical University, Kashihara.
Masui. 1994 Mar;43(3):374-7.
We studied the relaxation property of priming or precurarization vecuronium dose (0.015 mg.kg-1) on the diaphragm and the abductor digiti minimi muscle in 8 healthy patients undergoing elective surgery. Patients had control ventilation (PETCO2: 35 - 40 mmHg) by the laryngeal mask under "thiopental-fentanyl-oxygen" anesthesia. Supra-maximal single twitch stimulation with 1 Hz frequency was applied to right phrenic and ulnar nerves. Electromyographic response was recorded using NEC Synax ER1100 (NEC, Sanei, Tokyo, Japan) by surface electrodes in the 8 th intercostal space and the hypothenar. Time to maximum blockade at the diaphragm was 189 +/- 37 sec, compared with 314 +/- 39 at the abductor digiti minimi muscle (P < 0.01). This result suggests that we should be careful about the respiratory state of primed or precurarized patients with small dose of vecuronium such as 0.015 mg.kg-1 administration.
我们研究了预注或预箭毒化剂量（0.015mg·kg-1）维库溴铵对8例择期手术健康患者膈肌和小指展肌的松弛特性。患者在“硫喷妥钠-芬太尼-氧气”麻醉下通过喉罩进行控制通气（呼气末二氧化碳分压：35 - 40mmHg）。以1Hz频率施加超强单次颤搐刺激至右侧膈神经和尺神经。使用NEC Synax ER1100（日本东京NEC三荣）通过第8肋间间隙和小鱼际表面电极记录肌电图反应。膈肌达到最大阻滞的时间为189±37秒，而小指展肌为314±39秒（P<0.01）。该结果表明，对于给予小剂量维库溴铵（如0.015mg·kg-1）预注或预箭毒化的患者，我们应密切关注其呼吸状态。
