Lees C, Campbell S, Jauniaux E, Brown R, Ramsay B, Gibb D, Moncada S, Martin J F
Department of Obstetrics and Gynaecology, King's College Hospital School of Medicine and Dentistry, Denmark Hill, London, UK.
Lancet. 1994 May 28;343(8909):1325-6. doi: 10.1016/s0140-6736(94)92468-6.
13 women admitted consecutively in preterm labour were recruited to an observational study of the effect of glyceryl trinitrate (GTN) patches on uterine contractions and prolongation of pregnancy. All twenty episodes of preterm labour (at 23-33 weeks' gestation) responded. 1 patient delivered because of cervical incompetence despite cessation of uterine contractions. The mean prolongation of pregnancy was 34 days. 8 babies have been born so far, and are progressing well. GTN patches appear to be a safe, well-tolerated, and non-invasive method of suppressing uterine contractions in preterm labour.
连续收治的13例早产孕妇被纳入一项关于硝酸甘油（GTN）贴片对子宫收缩及延长孕期影响的观察性研究。所有20例早产病例（妊娠23 - 33周）均有反应。1例患者尽管子宫收缩停止，但因宫颈机能不全而分娩。孕期平均延长34天。迄今为止，已有8名婴儿出生，且情况良好。硝酸甘油贴片似乎是一种安全、耐受性良好且无创的抑制早产子宫收缩的方法。
