Fiocchi A, Sala M, Signoroni P, Banderali G, Agostoni C, Riva E
5th Pediatric Department, University of Milan, Italy.
J Int Med Res. 1994 Jan-Feb;22(1):24-32. doi: 10.1177/030006059402200103.
The efficacy and safety of gamma-linolenic acid in the treatment of atopic dermatitis was evaluated. The children (mean age, 11.4 months) with atopic dermatitis (mean duration, 8.56 months) were openly treated with 3 g/day gamma-linolenic acid, for 28 days. Clinical evaluations were carried out every 7 days, and parents were asked to keep a diary, recording details of symptoms of eczema every day. Blood chemistry and immunological tests were done before and after treatment. None of the children showed complete recovery of symptoms. A gradual improvement in erythema, excoriations and lichenification was seen; significant differences were shown for itching (P < 0.01), and the use of antihistamines (P < 0.01). A significant rise in the percentage of circulating CD8 was found. No side-effects were recorded. Dietetic and pharmacological approaches are the basis of the treatment of atopic dermatitis and gamma-linolenic acid appears to be a safe and efficient additional therapy for infants and young children.
对γ-亚麻酸治疗特应性皮炎的疗效和安全性进行了评估。对患有特应性皮炎（平均病程8.56个月）的儿童（平均年龄11.4个月）采用每日3克γ-亚麻酸进行开放性治疗，为期28天。每7天进行一次临床评估，并要求家长记日记，每天记录湿疹症状的详细情况。在治疗前后进行血液化学和免疫测试。没有儿童症状完全恢复。观察到红斑、擦伤和苔藓化逐渐改善；瘙痒（P < 0.01）和抗组胺药的使用（P < 0.01）有显著差异。发现循环CD8百分比显著升高。未记录到副作用。饮食和药物治疗方法是特应性皮炎治疗的基础，γ-亚麻酸似乎是婴幼儿安全有效的辅助治疗方法。
