Leung J, Bouvier-Durand M, Morris P C, Guerrier D, Chefdor F, Giraudat J
Institut des Sciences Végétales, Centre National de la Recherche Scientifique UPR 40, Gif-sur-Yvette, France.
Science. 1994 Jun 3;264(5164):1448-52. doi: 10.1126/science.7910981.
The Arabidopsis ABI1 locus is essential for a wide spectrum of abscisic acid (ABA) responses throughout plant development. Here, ABI1 was shown to regulate stomatal aperture in leaves and mitotic activity in root meristems. The ABI1 gene was cloned and predicted to encode a signaling protein. Although its carboxyl-terminal domain is related to serine-threonine phosphatase 2C, the ABI1 protein has a unique amino-terminal extension containing an EF hand calcium-binding site. These results suggest that the ABI1 protein is a Ca(2+)-modulated phosphatase and functions to integrate ABA and Ca2+ signals with phosphorylation-dependent response pathways.
拟南芥ABI1基因座对于植物整个发育过程中广泛的脱落酸（ABA）反应至关重要。在此，研究表明ABI1可调节叶片气孔孔径和根分生组织中的有丝分裂活性。ABI1基因已被克隆，并预测其编码一种信号蛋白。尽管其羧基末端结构域与丝氨酸 - 苏氨酸磷酸酶2C相关，但ABI1蛋白具有一个独特的氨基末端延伸，其中包含一个EF手型钙结合位点。这些结果表明，ABI1蛋白是一种Ca(2+)调节的磷酸酶，其功能是将ABA和Ca2+信号与磷酸化依赖性反应途径整合起来。
