Zangerle R, Sarcletti M, Gallati H, Reibnegger G, Wachter H, Fuchs D
Department of Dermatology and Venerology, University of Innsbruck, Austria.
Int Arch Allergy Immunol. 1994;104(2):150-4. doi: 10.1159/000236723.
We assessed correlations between body mass index and plasma lipids, immune activation markers and the CD4+ T-cell count. The subjects of this cross-sectional study were randomly selected and comprised all those who attended the AIDS Out-Patient Clinic at the University Hospital in Innsbruck in March and April 1992. Patients with signs and symptoms of acute bacterial and secondary opportunistic infections were excluded. We investigated 63 individuals with HIV infection of whom 35 were asymptomatic, 8 had oral candidiasis, 4 had constitutional signs and symptoms and 16 had AIDS, for an association among body mass index, urinary neopterin, soluble tumor necrosis factor receptors (sTNFRs), plasma lipids, and the numbers of CD4+ T cells. The body mass index correlated inversely with urinary neopterin (rs = -0.42, p = 0.0009) and weakly with the numbers of CD4+ T cells (rs = 0.29, p = 0.02) but not with plasma lipids, sTNFRs and beta 2-microglobulin. The results show that body mass index correlates with immune activation. The data suggest that endogenous formation of interferon-gamma may be an important mediator of wasting in HIV infection, since this cytokine is responsible for the observed elevation of neopterin concentrations in body fluids.
我们评估了体重指数与血脂、免疫激活标志物以及 CD4+ T 细胞计数之间的相关性。这项横断面研究的对象是随机选取的，包括 1992 年 3 月和 4 月在因斯布鲁克大学医院艾滋病门诊就诊的所有患者。排除有急性细菌性感染和继发性机会性感染体征及症状的患者。我们调查了 63 例 HIV 感染患者，其中 35 例无症状，8 例有口腔念珠菌病，4 例有全身症状体征，16 例患有艾滋病，研究体重指数、尿新蝶呤、可溶性肿瘤坏死因子受体（sTNFRs）、血脂以及 CD4+ T 细胞数量之间的关联。体重指数与尿新蝶呤呈负相关（rs = -0.42，p = 0.0009），与 CD4+ T 细胞数量呈弱相关（rs = 0.29，p = 0.02），但与血脂、sTNFRs 和β2-微球蛋白无关。结果表明体重指数与免疫激活相关。数据提示，γ-干扰素的内源性生成可能是 HIV 感染中消瘦的重要介导因素，因为这种细胞因子导致了体液中新蝶呤浓度的升高。
