Zangerle R, Sarcletti M, Gallati H, Reibnegger G, Wachter H, Fuchs D
Department of Dermatology and Venereology, University of Innsbruck, Austria.
J Acquir Immune Defic Syndr (1988). 1994 Nov;7(11):1149-56.
We investigated 63 individuals with HIV infection, 34 of whom were asymptomatic (nine had oral candidiasis, four had constitutional signs and symptoms, and 16 had AIDS), for plasma lipids, soluble tumor necrosis factor receptor 75 (sTNF-R75) and other immune activation markers, namely urinary neopterin, beta 2-microglobulin, and the CD4+ T cell count. The median CD4+ T cell count was 318 x 10(6)/L. All individuals were allowed to have light breakfast in the morning; the venipuncture for the plasma lipids was done between 11 a.m. and 3 p.m.. Decreased plasma concentrations were found for total cholesterol, and HDL and LDL cholesterol in 3.2%, 46%, and 56% of the subjects, respectively. Plasma triglyceride levels were increased in 31.7% of the study population. The frequency and the extent of the decrease of HDL and LDL cholesterol and the increase in triglyceride levels were greater in those with a CD4+ T cell count below the median (p = 0.003, p = 0.05, and p = 0.01); when comparing individuals with CD4+ T cell counts above and below 500 x 10(6)/L (19 individuals), a difference was only found for HDL cholesterol (p = 0.01). Plasma levels of triglycerides correlated significantly however weakly with serum concentrations of sTNF-R75 (rs = 0.32, p = 0.01) but not at all with urinary neopterin or serum beta 2-microglobulin. HDL cholesterol correlated inversely with sTNF-R75 (rs = -0.53, p < 0.0001) and to a lesser extent with urinary neopterin (rs = -0.46, p = 0.0003) and beta 2-microglobulin (rs = -0.34, p = 0.008).(ABSTRACT TRUNCATED AT 250 WORDS)
我们调查了63名HIV感染者，其中34人无症状（9人患有口腔念珠菌病，4人有全身症状和体征，16人患有艾滋病），检测了他们的血脂、可溶性肿瘤坏死因子受体75（sTNF-R75）以及其他免疫激活标志物，即尿新蝶呤、β2-微球蛋白和CD4+T细胞计数。CD4+T细胞计数的中位数为318×10⁶/L。所有个体均允许在早上吃清淡早餐；血脂的静脉穿刺在上午11点至下午3点之间进行。分别在3.2%、46%和56%的受试者中发现总胆固醇、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）胆固醇的血浆浓度降低。31.7%的研究人群血浆甘油三酯水平升高。CD4+T细胞计数低于中位数的人群中，HDL和LDL胆固醇降低的频率和程度以及甘油三酯水平升高的情况更为明显（p = 0.003、p = 0.05和p = 0.01）；比较CD4+T细胞计数高于和低于500×10⁶/L的个体（19人）时，仅发现HDL胆固醇有差异（p = 0.01）。然而，血浆甘油三酯水平与sTNF-R75的血清浓度显著相关，但相关性较弱（rs = 0.32，p = 0.01），与尿新蝶呤或血清β2-微球蛋白则完全不相关。HDL胆固醇与sTNF-R75呈负相关（rs = -0.53，p < 0.0001），与尿新蝶呤的相关性较小（rs = -0.46，p = 0.0003），与β2-微球蛋白的相关性更小（rs = -0.34，p = 0.008）。（摘要截选至250字）
