Fleckenstein A E, Lookingland K J, Moore K E
Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824.
Brain Res. 1994 Feb 28;638(1-2):243-7. doi: 10.1016/0006-8993(94)90656-4.
The effect of histamine on the activity of noradrenergic neurons terminating in discrete regions of the diencephalon was examined in male rats. Noradrenergic neuronal activity was estimated by measuring the concentration of norepinephrine and its metabolite 3-methoxy-4-hydroxyphenylethyleneglycol [MHPG] in the medial zona incerta [MZI] and in the dorsomedial [DMN], periventricular [PeVN] and medial preoptic hypothalamic nuclei [MPN]. The intracerebroventricular administration of histamine effected a time-related increase in MHPG concentrations in the MZI, DMN, PeVN and MPN; these effects were blocked by the H1 antagonist mepyramine but not the H2 antagonist zolantidine. Neither mepyramine nor zolantidine affected basal MHPG concentrations in any of the brain regions examined. These results indicate that central administration of histamine increases the activity of noradrenergic neurons projecting to the diencephalon via an action at H1 but not H2 receptors.
在雄性大鼠中研究了组胺对终止于间脑离散区域的去甲肾上腺素能神经元活动的影响。通过测量内侧未定带（MZI）、背内侧（DMN）、室周（PeVN）和内侧视前下丘脑核（MPN）中去甲肾上腺素及其代谢产物3-甲氧基-4-羟基苯乙二醇[MHPG]的浓度来估计去甲肾上腺素能神经元的活动。脑室内注射组胺导致MZI、DMN、PeVN和MPN中MHPG浓度随时间增加；这些作用可被H1拮抗剂美吡拉敏阻断，但不能被H2拮抗剂佐兰替丁阻断。美吡拉敏和佐兰替丁均未影响所检测的任何脑区的基础MHPG浓度。这些结果表明，中枢给予组胺通过作用于H1而非H2受体增加投射到间脑的去甲肾上腺素能神经元的活动。
