膦甲酸钠用于抑制人类免疫缺陷病毒复制。
Foscarnet for suppression of human immunodeficiency virus replication.
作者信息
Fletcher C V, Collier A C, Rhame F S, Bennett D, Para M F, Beatty C C, Jones C E, Balfour H H
机构信息
Department of Pharmacy Practice, University of Minnesota, Minneapolis.
出版信息
Antimicrob Agents Chemother. 1994 Mar;38(3):604-7. doi: 10.1128/AAC.38.3.604.
Abstract
The effect of foscarnet against human immunodeficiency virus (HIV) was evaluated in nine HIV-infected individuals; six completed 28 days of induction therapy. The overall mean increase in CD4+ lymphocytes was 64 cells per mm3. The mean decline in the HIV antigen concentration was 108 pg/ml (P = 0.03), and suppression was related to systemic foscarnet exposure by a maximum-effect pharmacodynamic model.
摘要
对9名感染人类免疫缺陷病毒（HIV）的个体评估了膦甲酸钠对HIV的疗效；其中6人完成了28天的诱导治疗。CD4+淋巴细胞的总体平均增加量为每立方毫米64个细胞。HIV抗原浓度的平均下降量为108 pg/ml（P = 0.03），并且通过最大效应药效学模型，抑制作用与全身膦甲酸钠暴露相关。
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