Maeda K, Chung Y S, Kubo T, Nishimura M, Onoda N, Nitta A, Arimoto Y, Kato Y, Sowa M
First Dept. of Surgery, Osaka City University Medical School.
Gan To Kagaku Ryoho. 1994 May;21 Suppl 1:58-61.
The DNA ploidy pattern and the expression of proliferating cell nuclear antigen (PCNA) were investigated in 72 gastric carcinoma patients to determine the possible correlation between proliferation kinetics and biological behavior. The diploid pattern was more often observed in cases with mucosal invasion (m cancer) than other cases (sm or advanced cancer). The PCNA labelling index in cases with mucosal invasion was significantly lower than in other cases. The sm cancer was more often observed in patients with high PCNA labelling index (> or = 30%) and aneuploid pattern, while m cancer was more common in patients with low PCNA labelling (< 20%) index and diploid pattern. As a result of this study, we conclude that proliferating kinetics of m cancer may differ from that for sm or advanced cancer. Furthermore, DNA ploidy pattern and PCNA labelling index may be useful as a parameter of depth of invasion.
对72例胃癌患者的DNA倍体模式和增殖细胞核抗原（PCNA）表达进行了研究，以确定增殖动力学与生物学行为之间的可能相关性。与其他病例（sm癌或进展期癌）相比，黏膜浸润癌（m癌）病例中更常观察到二倍体模式。黏膜浸润癌病例的PCNA标记指数显著低于其他病例。sm癌更常见于PCNA标记指数高（≥30%）且为非整倍体模式的患者，而m癌在PCNA标记指数低（<20%）且为二倍体模式的患者中更为常见。作为本研究的结果，我们得出结论，m癌的增殖动力学可能与sm癌或进展期癌不同。此外，DNA倍体模式和PCNA标记指数可能作为浸润深度的一个参数有用。
