Heunis T D J, Dicks L M T
Department of Microbiology, University of Stellenbosch, Matieland, Stellenbosch 7602, South Africa.
J Biomed Biotechnol. 2010;2010. doi: 10.1155/2010/510682. Epub 2010 Jul 28.
Injury to the skin causes a breach in the protective layer surrounding the body. Many pathogens are resistant to antibiotics, rendering conventional treatment less effective. This led to the use of alternative antimicrobial compounds, such as silver ions, in skin treatment. In this review nanofibers, and the incorporation of natural antimicrobial compounds in these scaffolds, are discussed as an alternative way to control skin infections. Electrospinning as a technique to prepare nanofibers is discussed. The possibility of using these structures as drug delivery systems is investigated.
皮肤损伤会导致身体周围保护层出现破损。许多病原体对抗生素具有抗性,使得传统治疗效果降低。这促使在皮肤治疗中使用替代抗菌化合物,如银离子。在本综述中,将讨论纳米纤维以及在这些支架中掺入天然抗菌化合物作为控制皮肤感染的替代方法。还将讨论作为制备纳米纤维技术的静电纺丝。研究了使用这些结构作为药物递送系统的可能性。