Gilhar A, Enat R, Baruch Y
Skin Research Laboratory, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Acta Derm Venereol. 1994 Mar;74(2):93-4. doi: 10.2340/00015555749394.
The aim of the present study was to evaluate the number of Langerhans' cells (LC) in immunosuppressed liver transplanted patients, compared to patients with liver cirrhosis and healthy volunteers. The detection of LC was performed in the epidermal sheet of each patient by using indirect immunoperoxidase and ATPase staining. A significant reduction in the number of LC was found in the liver transplanted patients as compared to patients with liver cirrhosis and healthy volunteers. This reduction may be related to prolonged treatment with corticosteroids and azathioprine.
本研究的目的是评估免疫抑制的肝移植患者与肝硬化患者及健康志愿者相比，其朗格汉斯细胞（LC）的数量。通过间接免疫过氧化物酶和ATP酶染色，在每位患者的表皮片中检测LC。结果发现，与肝硬化患者及健康志愿者相比，肝移植患者的LC数量显著减少。这种减少可能与长期使用皮质类固醇和硫唑嘌呤治疗有关。
