Kelly G, Scheibner A, Murray E, Sheil R, Tiller D, Horvath J
J Cutan Pathol. 1987 Aug;14(4):202-6. doi: 10.1111/j.1600-0560.1987.tb01333.x.
The increased susceptibility of the skin of chronically immunosuppressed individuals to viral infections and sunlight-induced malignancies suggests specific drug-induced, dysfunction of local immune mechanisms within the sun-exposed skin of these individuals. To help understand the effect of immunosuppressive therapy alone in the absence of ultraviolet light on the immune system of skin, biopsies were collected from non-sun-exposed buttock skin of control, healthy volunteers and kidney transplant recipients immunosuppressed with either azathioprine/prednisone or cyclosporin A/prednisone and examined for incidences of T6+, and HLA-DR+ cells. No significant differences in the incidences of these 2 cell types were found (a) between control individuals and transplants recipients, (b) between transplant recipients receiving either of the immunosuppressive drug regimes, or (c) between transplant recipients who either had or had not developed skin cancer.
长期免疫抑制个体的皮肤对病毒感染和阳光诱发的恶性肿瘤易感性增加，这表明这些个体暴露于阳光下的皮肤中存在特定药物诱导的局部免疫机制功能障碍。为了帮助了解在无紫外线情况下单纯免疫抑制治疗对皮肤免疫系统的影响，从对照健康志愿者以及接受硫唑嘌呤/泼尼松或环孢素A/泼尼松免疫抑制的肾移植受者未暴露于阳光的臀部皮肤采集活检样本，并检测T6 +和HLA - DR +细胞的发生率。在以下方面未发现这两种细胞类型发生率的显著差异：(a)对照个体与移植受者之间；(b)接受任何一种免疫抑制药物方案的移植受者之间；或(c)已发生或未发生皮肤癌的移植受者之间。
