Aguayo S M
Pulmonary Disease Section, Atlanta Department of Veterans Affairs Medical Center, Decatur, GA 30033.
Am J Respir Crit Care Med. 1994 Jun;149(6):1692-8. doi: 10.1164/ajrccm.149.6.7911710.
There is a subgroup of cigarette smokers who are more susceptible than others to the deleterious effects of cigarette smoke and to chronic airflow obstruction. The study of histopathologic and physiologic differences between these "susceptible" smokers and "resistant" smokers, who do not develop clinically significant airflow obstruction, may lead to better understanding of host factors that determine individual susceptibility to cigarette smoke. This report puts forth the hypothesis that individual differences in number or function of pulmonary neuroendocrine cells may play an important role in determining whether cigarette smokers develop chronic airflow obstruction and perhaps other smoking-related disorders. In this context, pulmonary neuroendocrine cells and bombesin-like peptides are discussed, emphasizing those aspects most relevant to the pathobiologic consequences of cigarette smoking.
有一部分吸烟者比其他人更容易受到香烟烟雾的有害影响以及慢性气流阻塞的影响。研究这些“易感”吸烟者与未出现具有临床意义的气流阻塞的“抗性”吸烟者之间的组织病理学和生理学差异，可能有助于更好地理解决定个体对香烟烟雾易感性的宿主因素。本报告提出一个假说，即肺神经内分泌细胞数量或功能的个体差异可能在决定吸烟者是否会发生慢性气流阻塞以及可能的其他吸烟相关疾病方面发挥重要作用。在此背景下，讨论了肺神经内分泌细胞和蛙皮素样肽，重点强调了与吸烟病理生物学后果最相关的那些方面。
