Sanchez R, Kanarek L, Koninkx J, Hendriks H, Lintermans P, Bertels A, Charlier G, Van Driessche E
Vrije Universiteit Brussel, Laboratorium Chemie der Proteïnen, Sint-Genesius-Rode, Belgium.
Microb Pathog. 1993 Dec;15(6):207-19. doi: 10.1006/mpat.1993.1090.
Enterotoxigenic Escherichia coli strains expressing F17 fimbriae bind to the intestinal mucosa of young calves. F17 fimbriae recognize receptors present in the mucus layer and the brush-border membranes from duodenum, jejunum and ileum. The adhesion of E. coli F17 can be inhibited by several glycoproteins. Adhesion is also inhibited by pretreatment of mucus and brush-border membranes with sodium metaperiodate. The use of glycoconjugates as potential adhesion-blockers is further discussed.
表达F17菌毛的产肠毒素大肠杆菌菌株可黏附于幼龄犊牛的肠黏膜。F17菌毛可识别存在于黏液层以及十二指肠、空肠和回肠刷状缘膜中的受体。几种糖蛋白可抑制大肠杆菌F17的黏附。用偏高碘酸钠预处理黏液和刷状缘膜也可抑制黏附。本文进一步讨论了使用糖缀合物作为潜在黏附阻断剂的情况。
