• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino acid 200 in beta-tubulin isotype 1.

作者信息

Kwa M S, Veenstra J G, Roos M H

机构信息

Department of Parasitology and Tropical Veterinary Medicine, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.

出版信息

Mol Biochem Parasitol. 1994 Feb;63(2):299-303. doi: 10.1016/0166-6851(94)90066-3.

DOI:10.1016/0166-6851(94)90066-3
PMID:7911975
Abstract
摘要

相似文献

1
Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino acid 200 in beta-tubulin isotype 1.捻转血矛线虫对苯并咪唑的抗性与β-微管蛋白1型中第200位氨基酸的保守突变有关。
Mol Biochem Parasitol. 1994 Feb;63(2):299-303. doi: 10.1016/0166-6851(94)90066-3.
2
Detection of benzimidazole resistance in Haemonchus contortus using RFLP-PCR technique.利用限制性片段长度多态性聚合酶链反应（RFLP-PCR）技术检测捻转血矛线虫对苯并咪唑的抗性
Vet Parasitol. 2006 Jun 15;138(3-4):301-7. doi: 10.1016/j.vetpar.2006.02.003. Epub 2006 Mar 29.
3
Effect of selection for benzimidazole resistance in Haemonchus contortus on beta-tubulin isotype 1 and isotype 2 genes.捻转血矛线虫对苯并咪唑抗性的选择对β-微管蛋白1型和2型基因的影响。
Biochem Biophys Res Commun. 1993 Mar 15;191(2):413-9. doi: 10.1006/bbrc.1993.1233.
4
Development of a tetra-primer ARMS-PCR for detecting the E198A SNP in the isotype-1 β-tubulin gene of Haemonchus contortus populations in China.用于检测中国捻转血矛线虫群体1型β-微管蛋白基因中E198A单核苷酸多态性的四引物扩增受阻突变体系聚合酶链反应的建立
Vet Parasitol. 2018 Mar 15;252:127-130. doi: 10.1016/j.vetpar.2018.01.021. Epub 2018 Jan 31.
5
Genetic analysis of a relationship between macrocyclic lactone and benzimidazole anthelmintic selection on Haemonchus contortus.大环内酯与苯并咪唑驱虫药对捻转血矛线虫选择作用之间关系的遗传分析。
Pharmacogenet Genomics. 2008 Feb;18(2):129-40. doi: 10.1097/FPC.0b013e3282f4711d.
6
Molecular characterisation of beta-tubulin genes present in benzimidazole-resistant populations of Haemonchus contortus.捻转血矛线虫苯并咪唑抗性群体中β-微管蛋白基因的分子特征分析
Mol Biochem Parasitol. 1993 Jul;60(1):133-43. doi: 10.1016/0166-6851(93)90036-w.
7
Genetic evidence for the spread of a benzimidazole resistance mutation across southern India from a single origin in the parasitic nematode Haemonchus contortus.关于一种苯并咪唑抗性突变从寄生线虫捻转血矛线虫在印度南部的单一源头传播开来的遗传学证据。
Int J Parasitol. 2015 Sep;45(11):721-8. doi: 10.1016/j.ijpara.2015.04.007. Epub 2015 Jun 19.
8
Genetic variability of the beta-tubulin genes in benzimidazole-susceptible and -resistant strains of Haemonchus contortus.捻转血矛线虫苯并咪唑敏感和抗性品系中β-微管蛋白基因的遗传变异性
Genetics. 1994 Sep;138(1):103-10. doi: 10.1093/genetics/138.1.103.
9
Contrasting patterns of isotype-1 β-tubulin allelic diversity in Haemonchus contortus and Haemonchus placei in the southern USA are consistent with a model of localised emergence of benzimidazole resistance.在美国南部，捻转血矛线虫和马歇尔血矛线虫的 I 型β-微管蛋白等位基因多样性的对比模式与苯并咪唑类药物耐药性局部出现的模型一致。
Vet Parasitol. 2020 Oct;286:109240. doi: 10.1016/j.vetpar.2020.109240. Epub 2020 Sep 9.
10
Two benzimidazole resistance-associated SNPs in the isotype-1 β-tubulin gene predominate in Haemonchus contortus populations from eight regions in China.在中国八个地区的捻转血矛线虫种群中，同种型-1β-微管蛋白基因中的两个与苯并咪唑抗性相关的单核苷酸多态性占主导地位。
Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):199-206. doi: 10.1016/j.ijpddr.2016.10.001. Epub 2016 Oct 5.

引用本文的文献

1
Similar patterns of benzimidazole resistance alleles in ovine gastrointestinal nematodes from Western Canada and Eastern United States supports their shared origins and subsequent spread.加拿大西部和美国东部绵羊胃肠道线虫中苯并咪唑抗性等位基因的相似模式支持了它们共同的起源以及随后的传播。
Int J Parasitol Drugs Drug Resist. 2025 Oct 7;29:100620. doi: 10.1016/j.ijpddr.2025.100620.
2
Nemabiome metabarcoding of wild conservation bison herds and co-grazing cattle reveals different species compositions and low-level benzimidazole resistance.对野生保护野牛群和共同放牧的牛群进行线虫生物群落代谢物条形码分析，揭示了不同的物种组成和低水平的苯并咪唑抗性。
Int J Parasitol Parasites Wildl. 2025 Sep 5;28:101134. doi: 10.1016/j.ijppaw.2025.101134. eCollection 2025 Dec.
3
Faecal egg count reduction test, deep amplicon sequencing of isotype-1 β-tubulin gene and in ovo larval development assay reveal susceptibility to benzimidazoles of porcine nematodes Oesophagostomum spp. and Ascaris suum in outdoor-reared pigs in Germany.粪便虫卵计数减少试验、1型β-微管蛋白基因的深度扩增子测序以及鸡胚幼虫发育试验揭示了德国室外饲养猪体内猪食道口线虫和猪蛔虫对苯并咪唑类药物的敏感性。
Int J Parasitol Drugs Drug Resist. 2025 Aug 28;29:100612. doi: 10.1016/j.ijpddr.2025.100612.
4
Albendazole specifically disrupts microtubules and protein turnover in the tegument of the cestode Mesocestoides corti.阿苯达唑特异性地破坏绦虫中殖孔绦虫皮层中的微管和蛋白质周转。
PLoS Pathog. 2025 Jun 4;21(6):e1013221. doi: 10.1371/journal.ppat.1013221. eCollection 2025 Jun.
5
Molecular epidemiology of Ascaris lumbricoides following multiple rounds of community-wide treatment.多轮社区范围治疗后蛔虫的分子流行病学
Nat Commun. 2025 May 9;16(1):4321. doi: 10.1038/s41467-025-59316-x.
6
Independent mechanisms of benzimidazole resistance across nematodes.线虫中苯并咪唑抗性的独立机制。
bioRxiv. 2025 Mar 15:2025.03.13.643047. doi: 10.1101/2025.03.13.643047.
7
Naturally occurring variation in a cytochrome P450 modifies thiabendazole responses independently of beta-tubulin.细胞色素P450的自然变异独立于β-微管蛋白修饰噻苯达唑反应。
PLoS Pathog. 2025 Jan 14;21(1):e1012602. doi: 10.1371/journal.ppat.1012602. eCollection 2025 Jan.
8
New Insights on Tools for Detecting β-Tubulin Polymorphisms in Using rhAmp SNP Genotyping.利用rhAmp SNP基因分型检测β-微管蛋白多态性工具的新见解。
Animals (Basel). 2024 May 23;14(11):1545. doi: 10.3390/ani14111545.
9
Worldwide absence of canonical benzimidazole resistance-associated mutations within β-tubulin genes from Ascaris.全球范围内从蛔虫的β-微管蛋白基因中不存在经典苯并咪唑类药物耐药相关突变。
Parasit Vectors. 2024 May 16;17(1):225. doi: 10.1186/s13071-024-06306-5.
10
Quantitative tests of albendazole resistance in beta-tubulin mutants.β-微管蛋白突变体中阿苯达唑抗性的定量测试。
bioRxiv. 2024 Apr 13:2024.04.11.589070. doi: 10.1101/2024.04.11.589070.