Davis C B, Littman D R
Department of Microbiology and Immunology, University of California, San Francisco 94143-0414.
Curr Opin Immunol. 1994 Apr;6(2):266-72. doi: 10.1016/0952-7915(94)90100-7.
Thymocytes co-expressing the CD4 and CD8 co-receptors differentiate into mature T cells that express either CD4 or CD8 and have helper or cytotoxic functions, respectively. Recent studies indicate that commitment to the CD4+ or CD8+ lineages occurs stochastically, but retention of the appropriate co-receptor is required to complete development.
