I类主要组织相容性复合体特异性T细胞发育中的随机成分。
Stochastic component to development of class I major histocompatibility complex-specific T cells.
作者信息
Itano A, Kioussis D, Robey E
机构信息
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
出版信息
Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):220-4. doi: 10.1073/pnas.91.1.220.
Abstract
The mechanism by which an initially uncommitted cell chooses between alternative fates is a central issue in developmental biology. In the mammalian thymus, CD4 helper T cells and CD8 cytotoxic T cells arise from a common precursor that expresses both CD4 and CD8. The choice between the CD4 and CD8 lineage is linked to the specificity of the T-cell antigen receptor expressed by a thymocyte, but whether lineage commitment is stochastic or instructed has not been definitively resolved. We present evidence that expression of a constitutive CD8 transgene during thymic selection permits development of mature CD4 cells bearing the class I-restricted F5 T-cell antigen receptor. These results suggest that there is a stochastic component to the development of class I major histocompatibility complex-restricted T cells.
摘要
一个最初未定向的细胞在不同命运之间进行选择的机制是发育生物学中的核心问题。在哺乳动物胸腺中，CD4辅助性T细胞和CD8细胞毒性T细胞源自共同的前体细胞，该前体细胞同时表达CD4和CD8。CD4和CD8谱系之间的选择与胸腺细胞所表达的T细胞抗原受体的特异性相关，但谱系定向是随机的还是受指令调控的尚未得到明确解决。我们提供的证据表明，在胸腺选择过程中组成型CD8转基因的表达允许携带I类限制性F5 T细胞抗原受体的成熟CD4细胞发育。这些结果表明，I类主要组织相容性复合体限制性T细胞的发育存在随机成分。
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本文引用的文献
1
Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen.表达针对流感核蛋白和内源性超抗原的T细胞受体的转基因小鼠中的阳性和阴性选择
Dev Immunol. 1993;3(3):159-74. doi: 10.1155/1993/98015.
2
Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.T淋巴细胞成熟亚群分化中随机机制的证据。
Cell. 1993 Apr 23;73(2):237-47. doi: 10.1016/0092-8674(93)90226-g.
3
Another view of the selective model of thymocyte selection.胸腺细胞选择的选择性模型的另一种观点。
Cell. 1993 Apr 23;73(2):225-36. doi: 10.1016/0092-8674(93)90225-f.
4
Separation of lymphocytes on antibody-coated plates.在抗体包被的平板上分离淋巴细胞。
Methods Enzymol. 1984;108:118-24.
5
T cell selection in the thymus.胸腺中的T细胞选择。
Immunol Rev. 1988 Jan;101:173-90. doi: 10.1111/j.1600-065x.1988.tb00737.x.
6
Positive selection of antigen-specific T cells in thymus by restricting MHC molecules.通过限制MHC分子在胸腺中进行抗原特异性T细胞的阳性选择。
Nature. 1988 Oct 20;335(6192):730-3. doi: 10.1038/335730a0.
7
Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice.转基因小鼠中携带CD8的T淋巴细胞上抗原受体的选择性表达。
Nature. 1988 Sep 15;335(6187):271-4. doi: 10.1038/335271a0.
8
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Nature. 1988 Sep 15;335(6187):208-10. doi: 10.1038/335208a0.
9
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J Immunol. 1989 Nov 15;143(10):3379-84.
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