Lamers C B
Dept. of Gastroenterology-Hepatology, University Hospital, Leiden, The Netherlands.
Scand J Gastroenterol Suppl. 1993;200:96-7.
Despite its high prevalence, our understanding of the pathophysiology and therapy of functional or nonulcer dyspepsia is very limited. Because of differences in definition, diagnostic work-up and patient or population characteristics, interpretation of published studies on functional dyspepsia is difficult. Recently developed new proposals, such as the role of Helicobacter pylori in the pathogenesis and the clinical relevance of dividing dyspeptic patients into subgroups based on clusters of symptoms, have appeared to be less promising than originally thought. No new therapies have been developed that have been shown to be superior to H2-receptor antagonists. New approaches have to be taken to unravel the pathogenesis and to determine the optimal therapy of functional dyspepsia.
尽管功能性消化不良或非溃疡性消化不良的患病率很高，但我们对其病理生理学和治疗方法的了解非常有限。由于定义、诊断检查以及患者或人群特征的差异，对已发表的关于功能性消化不良研究的解读很困难。最近提出的一些新观点，如幽门螺杆菌在发病机制中的作用以及根据症状群将消化不良患者分为亚组的临床意义，似乎并不像最初认为的那样有前景。目前尚未开发出比H2受体拮抗剂更有效的新疗法。必须采取新方法来阐明发病机制并确定功能性消化不良的最佳治疗方法。
