Campkin N T, Hood J R, Feldman S A
Department of Anaesthetics, Royal Hampshire County Hospital, Winchester, Hants.
Anaesthesia. 1994 Jun;49(6):501-2. doi: 10.1111/j.1365-2044.1994.tb03520.x.
To assess rate of biophase recovery, the recovery from neuromuscular block with mivacurium in the isolated forearm was compared with that from vecuronium simultaneously administered into the other isolated forearm of six volunteers. In a second series of similar experiments, recovery from doxacurium was compared with that from vecuronium. Neuromuscular block was monitored using the adductor pollicis mechanomyographic response to ulnar nerve stimulation at 0.2 Hz. Comparable degrees of maximum twitch tension depression were obtained in each series. In the first series, mean (SD) 25-75% recovery index for mivacurium was 8.4 (1.5) min and 10.5 (1.9) min for vecuronium. In the second series, mean (SD) recovery index for doxacurium was 18.3 (4.2) min and 12.2 (5.0) min for vecuronium. The recovery index of doxacurium in the isolated forearm was significantly greater, and the recovery index of mivacurium significantly less, than the recovery index of simultaneously administered vecuronium. Mivacurium block in the isolated forearm recovers rapidly, although not faster than after systemic injection; this is consistent with a drug that is retained in the biophase despite rapid plasma metabolism. Doxacurium block in the isolated forearm is slow to recover, compared with vecuronium; this suggests that high affinity for the biophase may contribute to its long duration of action.
为评估生物相恢复率，将六名志愿者的孤立前臂中米库氯铵所致神经肌肉阻滞的恢复情况，与同时注入另一孤立前臂的维库溴铵所致神经肌肉阻滞的恢复情况进行比较。在另一系列类似实验中，将多沙库铵的恢复情况与维库溴铵进行比较。使用拇收肌对0.2Hz尺神经刺激的肌电图反应监测神经肌肉阻滞。每一系列实验中均获得了相当程度的最大抽搐张力抑制。在第一系列实验中，米库氯铵的平均（标准差）25% - 75%恢复指数为8.4（1.5）分钟，维库溴铵为10.5（1.9）分钟。在第二系列实验中，多沙库铵的平均（标准差）恢复指数为18.3（4.2）分钟，维库溴铵为12.2（5.0）分钟。孤立前臂中多沙库铵的恢复指数显著高于同时注入的维库溴铵，而米库氯铵的恢复指数显著低于维库溴铵。孤立前臂中米库氯铵阻滞的恢复迅速，尽管不比全身注射后更快；这与一种尽管血浆代谢迅速但仍保留在生物相中的药物相符。与维库溴铵相比，孤立前臂中多沙库铵阻滞的恢复缓慢；这表明对生物相的高亲和力可能导致其作用时间延长。
