McClure N, Healy D L, Rogers P A, Sullivan J, Beaton L, Haning R V, Connolly D T, Robertson D M
Monash University Department of Obstetrics and Gynaecology, Monash Medical Centre, Victoria, Australia.
Lancet. 1994 Jul 23;344(8917):235-6. doi: 10.1016/s0140-6736(94)93001-5.
We investigated the role of vascular endothelial growth factor (VEGF) in ovarian hyperstimulation syndrome (OHSS). Two similar peaks of permeability activity were seen in OHSS ascites and liver ascites spiked with recombinant human VEGF (rhVEGF); no activity was seen in control liver ascites. Incubation with rhVEGF antiserum decreased activity in the two OHSS peaks by 79% and 65% and the two spiked liver peaks by 49% and 50%. Control serum produced 24% and 27%, and 17% and 0% reductions, respectively. This is evidence that the major capillary permeability agent in OHSS ascites fluid is VEGF.
我们研究了血管内皮生长因子（VEGF）在卵巢过度刺激综合征（OHSS）中的作用。在OHSS腹水以及添加重组人VEGF（rhVEGF）的肝腹水中观察到两个相似的通透性活性峰值；在对照肝腹水中未观察到活性。用rhVEGF抗血清孵育使两个OHSS峰值的活性分别降低了79%和65%，使两个添加rhVEGF的肝腹水峰值的活性分别降低了49%和50%。对照血清分别使活性降低了24%和27%，以及17%和0%。这证明OHSS腹水液中的主要毛细血管通透剂是VEGF。
