氯霉素和磺胺苯唑对人中环磷酰胺生物转化的影响。
The effect of chloramphenicol and sulphaphenazole on the biotransformation of cyclophosphamide in man.
作者信息
Faber O K, Mouridsen H T, Skovsted L
出版信息
Br J Clin Pharmacol. 1975 Jun;2(3):281-5. doi: 10.1111/j.1365-2125.1975.tb01589.x.
Abstract
1 The metabolism of cyclophosphamide was investigated before and following treatment with chloramphenicol (five subject) and sulphaphenazole (seven subjects). 2 The biotransformation of cyclophosphamide was retarded after chloramphenicol treatment as indicated by prolongation in the mean serum half-life from 7.5 h to 11.5 h combined with decreased peak activity and integrated concentrations of metabolites. 3 In the sulphaphenazole treated subjects the rate of biotransformation of cyclophosphamide was significantly inhibited in two, unaltered in three and enhanced in two. The inconsistency of the results is discussed.
摘要
- 在使用氯霉素（5名受试者）和磺胺苯吡唑（7名受试者）治疗前后，对环磷酰胺的代谢情况进行了研究。2. 氯霉素治疗后，环磷酰胺的生物转化受到抑制，表现为平均血清半衰期从7.5小时延长至11.5小时，同时代谢物的峰值活性和综合浓度降低。3. 在接受磺胺苯吡唑治疗的受试者中，环磷酰胺的生物转化速率在两名受试者中受到显著抑制，三名受试者中未改变，两名受试者中增强。对结果的不一致性进行了讨论。
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[ON THE ACTIVATION OF CYCLOPHOSPHAMIDE IN VIVO AND IN VITRO].[关于环磷酰胺在体内和体外的活化作用]
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SULPHAPHENAZOLE-INDUCED HYPOGLYCAEMIC ATTACKS IN TOLBUTAMIDE-TREATED DIABETICS.磺胺苯吡唑诱发甲苯磺丁脲治疗的糖尿病患者低血糖发作
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Effect of chloramphenicol on the metabolism and lethality of cyclophosphamide in rats.氯霉素对大鼠体内环磷酰胺代谢及致死性的影响。
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