Cullen W K, Rowan M J
Department of Pharmacology and Therapeutics, Trinity College, Dublin, Ireland.
Pharmacol Biochem Behav. 1994 May;48(1):301-6. doi: 10.1016/0091-3057(94)90531-2.
Ultrasonic (22 kHz) vocalisation in response to a mildly aversive foot shock was measured in the dark compartment of a light-dark box both immediately and 24 h after the shock. Gepirone (1 and 5 mg/kg, IP) produced a reduction in the duration of vocalisation at both times. Although a metabolic inhibitor, proadifen (40 mg/kg) did not reduce this effect of gepirone, the gepirone hepatic metabolite, 1-(2-pyrimidinyl)-piperazine (1-PP, 1 mg/kg), was also active in the test. Performance of a 24 h step-through passive avoidance task was impaired by gepirone only at a dose, 5 mg/kg, which also reduced spontaneous locomotor and rearing activity in the apparatus. It would appear that mild foot shock-evoked ultrasonic vocalisation may provide a more sensitive indicator of the effect of gepirone and related drugs on the affective response of rats to aversive stimulation.
在明暗箱的暗室中，于足部受到轻度厌恶电击后立即以及24小时后，测量了大鼠对该电击的超声波（22千赫兹）发声。吉哌隆（1和5毫克/千克，腹腔注射）在两个时间点均使发声持续时间缩短。虽然代谢抑制剂普罗地芬（40毫克/千克）并未减弱吉哌隆的这种作用，但吉哌隆的肝脏代谢产物1-(2-嘧啶基)-哌嗪（1-PP，1毫克/千克）在该测试中也具有活性。仅在5毫克/千克的剂量下，吉哌隆才会损害24小时穿梭式被动回避任务的表现，该剂量同时还降低了大鼠在实验装置中的自发运动和竖毛活动。似乎轻度足部电击诱发的超声波发声可能为吉哌隆及相关药物对大鼠厌恶刺激情感反应的影响提供更敏感的指标。
