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Simultaneous determination of buspirone, gepirone, ipsapirone and their common metabolite 1-(2-pyrimidinyl)piperazine in rat plasma and brain by high-performance liquid chromatography.

作者信息

Bianchi G, Caccia S

机构信息

Istituto de Ricerche Farmacologiche Mario Negri, Milan, Italy.

出版信息

J Chromatogr. 1988 Oct 14;431(2):477-80. doi: 10.1016/s0378-4347(00)83123-0.

DOI:10.1016/s0378-4347(00)83123-0
PMID:2907515
Abstract
摘要

相似文献

1
Simultaneous determination of buspirone, gepirone, ipsapirone and their common metabolite 1-(2-pyrimidinyl)piperazine in rat plasma and brain by high-performance liquid chromatography.
J Chromatogr. 1988 Oct 14;431(2):477-80. doi: 10.1016/s0378-4347(00)83123-0.
2
The alpha 2-adrenoceptor antagonist activity of ipsapirone and gepirone is mediated by their common metabolite 1-(2-pyrimidinyl)-piperazine (PmP).伊沙匹隆和吉哌隆的α2-肾上腺素能受体拮抗活性由它们的共同代谢产物1-(2-嘧啶基)-哌嗪（PmP）介导。
Eur J Pharmacol. 1988 Jul 14;151(3):365-71. doi: 10.1016/0014-2999(88)90532-8.
3
Simultaneous high-performance liquid chromatographic analysis of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in plasma using electrochemical detection.采用电化学检测法同时对血浆中丁螺环酮及其代谢物1-(2-嘧啶基)-哌嗪进行高效液相色谱分析。
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Evaluation of the alpha 2-adrenoceptor blocking properties of buspirone and ipsapirone in healthy subjects. Relationship with the plasma concentration of the common metabolite 1-(2-pyrimidinyl)-piperazine.在健康受试者中对丁螺环酮和伊沙匹隆的α2-肾上腺素能受体阻断特性进行评估。与共同代谢产物1-(2-嘧啶基)-哌嗪血浆浓度的关系。
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Effect of food on the bioavailability of gepirone in humans.
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Gepirone and 1-(2-pyrimidinyl)-piperazine-induced reduction of aversively evoked ultrasonic vocalisation in the rat.吉哌隆和1-(2-嘧啶基)哌嗪对大鼠厌恶诱发的超声发声的抑制作用。
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Determination of buspirone and 1-(2-pyrimidinyl)piperazine in plasma samples by high-performance liquid chromatography.采用高效液相色谱法测定血浆样品中丁螺环酮和1-(2-嘧啶基)哌嗪的含量。
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Interactions of buspirone with itraconazole and rifampicin: effects on the pharmacokinetics of the active 1-(2-pyrimidinyl)-piperazine metabolite of buspirone.
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Oral buspirone causes a shift in the dose-response curve between the elevated-plus maze and Vogel conflict tests in Long-Evans rats: relation of brain levels of buspirone and 1-PP to anxiolytic action.口服丁螺环酮可使长 Evans 大鼠在高架十字迷宫和 Vogel 冲突试验中的剂量反应曲线发生偏移：丁螺环酮和 1-PP 的脑内水平与抗焦虑作用的关系。
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引用本文的文献

1
Clinical pharmacokinetics and pharmacodynamics of buspirone, an anxiolytic drug.抗焦虑药物丁螺环酮的临床药代动力学与药效学
Clin Pharmacokinet. 1999 Apr;36(4):277-87. doi: 10.2165/00003088-199936040-00003.
2
Evaluation of the alpha 2-adrenoceptor blocking properties of buspirone and ipsapirone in healthy subjects. Relationship with the plasma concentration of the common metabolite 1-(2-pyrimidinyl)-piperazine.在健康受试者中对丁螺环酮和伊沙匹隆的α2-肾上腺素能受体阻断特性进行评估。与共同代谢产物1-(2-嘧啶基)-哌嗪血浆浓度的关系。
Br J Clin Pharmacol. 1995 Mar;39(3):243-9. doi: 10.1111/j.1365-2125.1995.tb04443.x.