Ronald P J, Robertson J R, Elton R A
Edinburgh Drug Addiction Study, University of Edinburgh, Scotland, UK.
AIDS. 1994 Mar;8(3):339-43. doi: 10.1097/00002030-199403000-00007.
To evaluate the effects of continued drug use and other cofactors on progression to AIDS among HIV-infected injecting drug users.
A prospective study.
The Muirhouse Medical Group in Edinburgh, Scotland, UK.
A total of 156 HIV-infected injecting drug users.
Progression to AIDS and low absolute CD4 counts.
Of this group, 48% will have progressed to AIDS 10 years after seroconversion. Age and low absolute T4 counts had a significant effect on progression to AIDS, with older patients progressing more rapidly. Sex had no significant effects on progression. Absolute CD4+ counts and the CD4:CD8 ratio were significant predictors of progression among the group. Concurrent heroin injecting increased the risk of progression to AIDS. No significant effects were observed for use of other drugs.
Our findings suggest that continued drug use may have an accelerating effect on progression to AIDS. Age also had an accelerating effect on progression, but sex had no significant effects. In general, the study group did not appear to progress at a different rate from other similar groups of HIV-infected individuals, despite the fact that this was a relatively young cohort. These data were based on accurate estimates of seroconversion dates.
评估持续吸毒及其他辅助因素对感染人类免疫缺陷病毒（HIV）的注射吸毒者发展为获得性免疫缺陷综合征（AIDS）的影响。
一项前瞻性研究。
英国苏格兰爱丁堡的缪尔豪斯医疗集团。
共156名感染HIV的注射吸毒者。
发展为AIDS及绝对CD4细胞计数低。
该组中，48%的人在血清转化10年后会发展为AIDS。年龄及绝对T4细胞计数低对发展为AIDS有显著影响，年龄较大的患者进展更快。性别对进展无显著影响。绝对CD4 +细胞计数及CD4:CD8比值是该组进展的显著预测指标。同时注射海洛因会增加发展为AIDS的风险。未观察到使用其他药物有显著影响。
我们的研究结果表明，持续吸毒可能对发展为AIDS有加速作用。年龄对进展也有加速作用，但性别无显著影响。总体而言，尽管该研究组相对年轻，但与其他类似的HIV感染个体组相比，其进展速度似乎并无差异。这些数据基于对血清转化日期的准确估计。
