Uhl G R
Molecular Neurobiology Branch, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
EXS. 1994;71:133-41. doi: 10.1007/978-3-0348-7330-7_14.
Classical genetic studies now provide fairly strong support to the idea that polygenic influences contribute to interindividual differences in vulnerability to drug abuse and dependence. Molecular genetic association studies have identified the D2 dopamine receptor gene as a candidate to contribute some of this genetic influence, although several cautions in utilizing association approaches must be recognized in interpreting their data. Clinical features of drug abuse that make association studies likely to play increasingly large roles in elucidating its underlying molecular genetics are discussed.
经典遗传学研究如今为多基因影响导致个体在药物滥用易感性和依赖性方面存在差异这一观点提供了相当有力的支持。分子遗传学关联研究已将D2多巴胺受体基因确定为可能导致部分此类遗传影响的候选基因，不过在解读其数据时必须认识到在运用关联方法时有几个需要注意的问题。文中讨论了药物滥用的临床特征，这些特征使得关联研究在阐明其潜在分子遗传学方面可能发挥越来越大的作用。
