Evseev V A, Vetrilé L A, Mukhina G L, Basharova L A
Ter Arkh. 1993;65(5):38-40.
Sera from 33 pollinosis patients aged 16-33 have been examined for autoantibodies to neuromediators serotonin and catecholamine, serum samples from 21 healthy subjects served controls. Antibodies to dopamine and norepinephrine (43.0 +/- 4.0, 35.0 +/- 0.0 rel. units) have been detected in 81.8% and 69.7% of the pollinosis patients, respectively. Serotonin antibodies (54.6 +/- 6.0 rel. units) occurred in the patients 3.8 times more frequently than in healthy subjects. Antibodies to neuromediators in quantities within 12.0 rel. units were recorded in 9.5-38.0% of the controls. It is suggested that induction of neuromediator antibodies synthesis may represent a compensatory mechanism of neuromediator metabolism control in pollinosis.
对33名年龄在16至33岁之间的花粉症患者的血清进行了检测，以寻找针对神经介质血清素和儿茶酚胺的自身抗体，选取21名健康受试者的血清样本作为对照。在花粉症患者中，分别有81.8%和69.7%检测到了针对多巴胺和去甲肾上腺素的抗体（相对单位分别为43.0±4.0、35.0±0.0）。患者中血清素抗体（相对单位为54.6±6.0）出现的频率是健康受试者的3.8倍。在9.5%至38.0%的对照中记录到神经介质抗体数量在12.0相对单位以内。提示神经介质抗体合成的诱导可能是花粉症中神经介质代谢控制的一种代偿机制。
