秋季花粉症患者从鼻炎到哮喘的自然病程：1096例患者的临床研究

[Natural course from rhinitis to asthma in the patients with autumnal pollinosis: a clinical study of 1096 patients].

作者信息

Yin Jia, Yue Feng-min, Wang Liang-lu, He Hai-juan, Xu Tao, Li Hong, Wen Li-ping, Sun Jing-lü, Gu Jian-qing, Han Shao-mei, Zhang Hong-yu, Ye Shi-tai

机构信息

Department of Allergy, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2006 Jun 20;86(23):1628-32.

PMID:16854304

Abstract

OBJECTIVE

To investigate the natural course from rhinitis to asthma in the patients with autumnal pollinosis.

METHODS

1096 patients with autumnal pollinosis, 488 males and 632 females, aged 38 +/- 14 (5 - 77), 511 with pure allergic rhinitis and 585 with allergic rhinitis complicated with asthma, underwent skin test of inhalant allergens, serum IgE specific to autumnal pollens, and questionnaire survey.

RESULTS

The age range of rhinitis induced by autumnal pollens was 2 - 75. The peak onset age of rhinitis was 15 - 44, and the peak onset age of asthma was 25 - 54. 33% of the rhinitis patients complicated with asthma (194/585) had their first attack of rhinitis and the first attack of asthma in the same year, 66% of them (386/585) had the first attack of asthma later than the first attack of rhinitis, and only 0.8% of them (5/585) had their first attack of asthma earlier than that of rhinitis. 37% of the patients with autumnal pollen allergic rhinitis (410/1096) developed asthma within 5 years, 47% (511/1096), within 9 years, 5% (58/1096) within 10 approximately 19 years, and 1.5% (16/1096) within 20 - 40 years.

CONCLUSION

Almost half of the patients with autumnal pollen allergic rhinitis develop to seasonal allergic asthma within 9 years.

摘要

目的

探讨秋季花粉症患者从鼻炎发展为哮喘的自然病程。

方法

1096例秋季花粉症患者，男488例，女632例，年龄38±14岁（5 - 77岁），其中单纯性变应性鼻炎511例，变应性鼻炎合并哮喘585例，进行吸入性变应原皮肤试验、秋季花粉特异性血清IgE检测及问卷调查。

结果

秋季花粉诱发鼻炎的年龄范围为2 - 75岁。鼻炎的发病高峰年龄为15 - 44岁，哮喘的发病高峰年龄为25 - 54岁。33%的鼻炎合并哮喘患者（194/585）鼻炎首次发作与哮喘首次发作在同一年，66%的患者（386/585）哮喘首次发作晚于鼻炎首次发作，仅0.8%的患者（5/585）哮喘首次发作早于鼻炎首次发作。37%的秋季花粉变应性鼻炎患者（410/1096）在5年内发展为哮喘，47%（511/1096）在9年内发展为哮喘，5%（58/1096）在10至19年内发展为哮喘，1.5%（16/1096）在20至40年内发展为哮喘。