Murad F
Molecular Geriatrics Corporation Lake Bluff, Illinois 60044.
Adv Pharmacol. 1994;26:19-33. doi: 10.1016/s1054-3589(08)60049-6.
The understanding of guanylyl cyclase regulation by nitrovasodilators has provided a great deal of information explaining the mechanisms of action of these cardiovascular drugs that have been in clinical use for the past century. The biochemical characterization of guanylyl cyclases and their regulation by NO have also permitted us, and others, to understand the mechanism of action of endothelium-dependent vasodilators and, subsequently, the roles for the nitric oxide-cyclic GMP signal transduction system in numerous cells and tissues. The potential importance of this signal transduction cascade is probably not fully appreciated since numerous additional studies obviously need to be performed. Also, as in many areas of science, serendipitous experiments and observations have added critical data to our present understanding in this field.
对硝基血管舒张剂调节鸟苷酸环化酶的了解，为解释这些在过去一个世纪中一直在临床使用的心血管药物的作用机制提供了大量信息。鸟苷酸环化酶的生化特性及其受一氧化氮的调节，也使我们以及其他人能够理解内皮依赖性血管舒张剂的作用机制，进而理解一氧化氮-环鸟苷酸信号转导系统在众多细胞和组织中的作用。由于显然还需要进行大量额外的研究，这个信号转导级联的潜在重要性可能尚未得到充分认识。此外，如同在许多科学领域一样，偶然的实验和观察为我们目前在该领域的理解增添了关键数据。
