Ostrovskaia R U, Molodavkin G M
Biull Eksp Biol Med. 1976 Sep;82(9):1073-6.
The effect of diazepam, depakin, thiosemicarbazide (TSC) and bicucullin on the spontaneous and incuced (by stimulation of the sciatic nerve) activity of the cells of the sensory-motor cortex was studied on the unanesthetized immobilized (curarized) albino rats. Diazepam proved to intensify the inhibitory phenomena, i.e. decreased the frequency of spontaneous discharges and prolonged the postactivation depression of the neuron impulsation (the inhibitory pause. Depakin increasing the GABA content in the brain acted similarly. The GABA-ergic receptors blocker, bicucullin and TSC, decreasing its content, on the contrary, weakened the inhibitory phenomena. There was also revealed a reversible antagonism between diazepam and bicucullin in their effect on the neuronal activity. The data obtained confirmed the supposition put forward formerly on the capacity of diazepam to intensify the effect of GABA on the neurons of the cerebral cortex.
在未麻醉的固定（箭毒化）白化大鼠身上，研究了地西泮、丙戊酸、氨基硫脲（TSC）和荷包牡丹碱对感觉运动皮层细胞自发活动以及（通过刺激坐骨神经）诱发活动的影响。结果表明，地西泮会增强抑制现象，即降低自发放电频率，并延长神经元冲动发放的激活后抑制（抑制性停顿）。增加大脑中γ-氨基丁酸（GABA）含量的丙戊酸也有类似作用。相反，GABA能受体阻断剂荷包牡丹碱和TSC降低了GABA含量，从而削弱了抑制现象。还发现地西泮和荷包牡丹碱在对神经元活动的影响上存在可逆拮抗作用。所得数据证实了先前提出的关于地西泮增强GABA对大脑皮层神经元作用能力的假设。
