Bulaev V M, Ostrovskaia R U
Biull Eksp Biol Med. 1977 Feb;83(2):183-5.
Acute experiments on nonanesthetized curare-treated rats with the recording of the neuronal activity of the cortex were conducted; a determination was made of the threshold doses in which diazepam influenced the spontaneous and induced activity of the neurons of the sensory-motor and optic cortex. Diazepam proved to depress the spontaneous and induced activity of the neurons of the sensory-motor and optic cortex. Diazepam proved to depress the spontaneous and induced activity of the neurons of the sensory-motor cortex in considerably lesser doses than the neuronal activity of the optic cortex. It is supposed that the neurons of the anterior portions of the cortex were more sensitive to diazepam than the neurons of the limbic structures and the reticular formation.
对用箭毒处理过的未麻醉大鼠进行了急性实验，记录其皮层神经元活动；测定了地西泮影响感觉运动皮层和视皮层神经元自发活动和诱发性活动的阈剂量。结果证明，地西泮可抑制感觉运动皮层和视皮层神经元的自发活动和诱发性活动。与对视皮层神经元活动的抑制相比，地西泮抑制感觉运动皮层神经元的自发活动和诱发性活动所需剂量要小得多。据推测，皮层前部的神经元比边缘结构和网状结构的神经元对地西泮更敏感。
