Taranenko V D
Neirofiziologiia. 1985;17(1):3-10.
Diazepam effect on paroxysmal electrical activity of an isolated auditory cortex slab and inhibitory responses of its neurons evoked by intracortical electrical stimulation were studied in experiments with cats. Diazepam (2 mg/kg, intravenously) evoked suppression of the paroxysmal electrical activity and increased the number of inhibited neurons both in acute isolated and three-week slabs as compared with the intact cortex. However in this case the number of disynaptic responses decreased, especially in the long-isolated slab. It is supposed that diazepam activated GABA-ergic inhibitory neurons synchronizing inhibition and increasing duration of IPSP. Its action is probably manifested in the first place in the very initial links of cortical neuronal chains.
在猫的实验中，研究了地西泮对离体听觉皮层薄片阵发性电活动以及皮层内电刺激诱发的神经元抑制反应的影响。与完整皮层相比，地西泮（2毫克/千克，静脉注射）可抑制急性离体和三周薄片中的阵发性电活动，并增加受抑制神经元的数量。然而，在这种情况下，双突触反应的数量减少，尤其是在长期离体的薄片中。据推测，地西泮激活了γ-氨基丁酸能抑制性神经元，使抑制同步并延长抑制性突触后电位的持续时间。其作用可能首先表现在皮层神经元链的最初环节。
