Vijayaraghavan S, Hitman G A, Kopelman P G
Medical Unit, Royal London Hospital, United Kingdom.
J Clin Endocrinol Metab. 1994 Aug;79(2):568-70. doi: 10.1210/jcem.79.2.7913935.
Obesity frequently clusters with hypertension, hyperlipidemia, non-insulin-dependent diabetes mellitus, and ischemic heart disease with hyperinsulinemia as syndrome X. Although central obesity has been recognized to have a strong genetic component, few candidate genes have been studied in this disorder. After a recently described association between the apolipoprotein-D (Apo-D) gene polymorphism and non-insulin-dependent diabetes mellitus by our group, we have now looked at a TaqI polymorphism of the Apo-D gene in two other components of syndrome X, namely obesity and hyperinsulinemia. Apo-D genotype differences were found between obese subjects (n = 57) and slim controls (n = 57; P = 0.006). Furthermore, in the obese group an association was found between the Apo-D genotype and fasting insulin (P < 0.001). Preliminary evidence, therefore, suggests that the TaqI Apo-D polymorphism can be used as a genetic marker for obesity and several components of syndrome X.
肥胖常与高血压、高脂血症、非胰岛素依赖型糖尿病以及伴有高胰岛素血症的缺血性心脏病聚集发生，称为X综合征。尽管已认识到中心性肥胖有很强的遗传成分，但针对该病症研究的候选基因却很少。在我们小组最近描述了载脂蛋白D（Apo-D）基因多态性与非胰岛素依赖型糖尿病之间的关联后，我们现在研究了Apo-D基因的TaqI多态性在X综合征的另外两个组成部分，即肥胖和高胰岛素血症中的情况。在肥胖受试者（n = 57）和苗条对照者（n = 57；P = 0.006）之间发现了Apo-D基因型差异。此外，在肥胖组中，发现Apo-D基因型与空腹胰岛素之间存在关联（P < 0.001）。因此，初步证据表明，TaqI Apo-D多态性可用作肥胖和X综合征几个组成部分的遗传标记。
