Felix D, Wu G Y, Wang S R
Division of Neurobiology, University of Berne, Switzerland.
Neurosci Lett. 1994 Mar 14;169(1-2):212-4. doi: 10.1016/0304-3940(94)90394-8.
In the present investigation, the effects of inhibitory amino acids and their antagonists were tested on isthmo-tectal projection in the pigeon. The majority of superficial tectal cells are inhibited following stimulation of the parvocellular division of nucleus isthmi. A smaller portion of tectal cells showed excitatory responses followed by an inhibitory period. Both inhibitory mechanisms are blocked by the specific gamma-aminobutyric acid (GABA)-antagonist bicuculline but not by strychnine. Our results support the idea that GABA acts as an inhibitory neurotransmitter in the pigeon isthmo-tectal pathways.
在本研究中，测试了抑制性氨基酸及其拮抗剂对鸽子峡核 - 视顶盖投射的影响。刺激峡核小细胞部后，大多数视顶盖浅层细胞受到抑制。一小部分视顶盖细胞表现出兴奋反应，随后是抑制期。两种抑制机制均被特异性γ-氨基丁酸（GABA）拮抗剂荷包牡丹碱阻断，而士的宁则无此作用。我们的结果支持这样一种观点，即GABA在鸽子峡核 - 视顶盖通路中作为一种抑制性神经递质起作用。
