Gottlieb S S
University of Maryland School of Medicine, Baltimore.
Curr Opin Cardiol. 1994 May;9(3):295-300. doi: 10.1097/00001573-199405000-00006.
The hypothesis that the long-term use of beta-blockers improves symptoms, cardiac function, and ejection fraction in patients with heart failure is increasingly being accepted. Multiple small studies have consistently demonstrated favorable outcomes with beta-blocker use, and a large-scale mortality study is now planned. However, important questions remain regarding which patients with heart failure should be treated and the mechanism by which beta-blockade exerts its beneficial effects. These questions undoubtedly need to be answered before physicians will be willing to prescribe these medications, the use of which is so counterintuitive.
长期使用β受体阻滞剂可改善心力衰竭患者的症状、心脏功能和射血分数这一假说越来越被人们所接受。多项小型研究一致证明使用β受体阻滞剂能带来良好的结果，目前正在计划开展一项大规模死亡率研究。然而，关于哪些心力衰竭患者应接受治疗以及β受体阻滞剂发挥有益作用的机制仍存在重要问题。在医生愿意开这些与直觉相悖的药物之前，这些问题无疑需要得到解答。
