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High-dose methylprednisolone treatment-induced changes in immunological parameters in progressive MS patients.

作者信息

Dufour A, Salmaggi A, La Mantia L, Eoli M, Nespolo A, Milanese C

机构信息

Istituto Nazionale Neurologico, C. Besta, Milano, Italy.

出版信息

Int J Neurosci. 1994 Mar;75(1-2):119-28. doi: 10.3109/00207459408986295.

DOI:10.3109/00207459408986295
PMID:7914185
Abstract

The effect of High-Dose Methylprednisolone (HD-MP) treatment on Peripheral Blood (PB) and Cerebrospinal Fluid (CSF) immune parameters was investigated in 9 patients with relapsing-progressive Multiple Sclerosis (MS). Short-time effects included reduction of the percentage of CD3+, CD4+ and CD4+CD45RA+ PB lymphocytes and increase in CD3-CD56+ cells. At the end of the treatment, only increase in PB CD19+ and in CSF CD8+, CD8+CD28+ and decrease of CSF CD4+CD45RA- and serum IL2R levels were observed. No changes in CD11a+CD4+, CD18+CD14+ PB cells were observed after treatment. The results further stress the complex and multifaceted action of HD-MP on immune parameters.

摘要

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