Gostishchev V K, Fedorovskiĭ N M
Khirurgiia (Mosk). 1994 May(5):55-7.
The authors analysed the complications and side reactions in extracorporeal connection with a donor xenospleen (ECCDS) and infusion of a xenosplenoperfusate in 205 patients with surgical purulent infection. In 127 patients ECCDS was conducted during traditional premedication (atropine 4 trimeperidine hydrochloride injected into a muscle 30-40 minutes before the procedure), in which case complications like anaphylactic shock, laryngo- and bronchospasm, Lyeil's syndrome, and angioneurotic edema occurred. ECCDS and infusion of a xenosplenoperfusate in 78 patients who received multicomponent premedication had practically no complications. Experience showed that multicomponent premedication including a complex of antihistaminic agents (diphenylhydramine hydrochloride++pipolphen+suprastin) and corticosteroids is a measure of reliable prevention of anaphylactic reactions both in primary and repeated xenosplenoperfusions. In severe endotoxicosis, immunocorrection by xenosplenoperfusion is most effective and safe (particularly in repeated procedures) when combined with preliminary efferent detoxification (hemosorption, exchange plasmapheresis) and multicomponent premedication.
作者分析了205例外科化脓性感染患者在与供体异种脾进行体外连接（ECCDS）及输注异种脾灌注液时的并发症和副作用。127例患者在传统术前用药（阿托品4mg、盐酸三甲苯丙胺在手术前30 - 40分钟肌肉注射）期间进行ECCDS，在此情况下发生了过敏休克、喉和支气管痉挛、莱尔综合征及血管神经性水肿等并发症。78例接受多组分术前用药的患者进行ECCDS及输注异种脾灌注液时几乎没有并发症。经验表明，包括抗组胺药（盐酸苯海拉明++吡苄明+氯苯那敏）和皮质类固醇复合物的多组分术前用药是在初次和重复异种脾灌注中可靠预防过敏反应的措施。在严重内毒素血症中，当与初步的传出解毒（血液吸附、交换血浆置换）和多组分术前用药联合使用时，异种脾灌注免疫纠正最为有效和安全（尤其是在重复操作中）。
