伏隔核中多巴胺与胆囊收缩素在精神兴奋剂奖赏及相关行为中的相互作用。
Nucleus accumbens dopamine-CCK interactions in psychostimulant reward and related behaviors.
作者信息
Vaccarino F J
机构信息
Department of Psychology, University of Toronto, Ontario, Canada.
出版信息
Neurosci Biobehav Rev. 1994 Summer;18(2):207-14. doi: 10.1016/0149-7634(94)90025-6.
The present paper provides an overview of dopamine (DA) and cholecystokinin (CCK) mechanisms that contribute to psychostimulant reward-related behaviors. Three different behavioral paradigms are focused on: intravenous psychostimulant reward, psychostimulant-induced locomotor activity, and psychostimulant-induced feeding. Based on evidence derived from these different behavioral paradigms, this paper reviews data indicating that nucleus accumbens CCK and DA play an important role in mediating reward. Neurobiological mechanisms are proposed to explain the functional relationship between CCK and DA in the nucleus accumbens.
本文概述了多巴胺（DA）和胆囊收缩素（CCK）在介导与精神兴奋剂奖赏相关行为中的作用机制。重点关注三种不同的行为范式：静脉注射精神兴奋剂奖赏、精神兴奋剂诱导的运动活动以及精神兴奋剂诱导的进食。基于从这些不同行为范式中获得的证据，本文回顾了表明伏隔核CCK和DA在介导奖赏中起重要作用的数据。提出了神经生物学机制来解释伏隔核中CCK和DA之间的功能关系。
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