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给大鼠注射别黄嘌呤后,肾上腺、睾丸和甲状腺中金的亚细胞定位。

Subcellular localization of gold in suprarenal testicle and thyroid glands after injection of allochrysine in rats.

作者信息

Manoubi L, Jaafoura M H, Skhiri-Zhioura A, el Hili A, Berry J P, Galle P

机构信息

Histology Laboratory, School of Medicine, Tunis, Tunisia.

出版信息

Cell Mol Biol (Noisy-le-grand). 1994 Jun;40(4):483-7.

PMID:7914784
Abstract

Gold injected under the form of anti-rheumatoid polyarthritis soluble solutions provokes, as observed by electron microscope, a deposit of crystalline micro-needles in different tissues, like in cells of adrenal and suprarenal glands, in Leydig cells of the testicles, in isolated thyrocytes and in thyroid endothelial cells. They are present as bundles, often of incurvated type, of high electron-density, present in lysosomes, which contain moreover a hyaline, emptied vesicle. These structures are named "aurosomes". The microanalysis, using the MS 46 (Cameca) and the Camebax (MBX) demonstrates that these crystalline structures are composed by gold associated with sulphur, and not with phosphate.

摘要

以抗类风湿性多关节炎可溶性溶液形式注射的金,通过电子显微镜观察发现,会在不同组织中形成结晶微针沉积物,如肾上腺和肾上腺细胞、睾丸间质细胞、分离的甲状腺细胞和甲状腺内皮细胞中。它们以束状形式存在,通常呈弯曲型,电子密度高,存在于溶酶体中,溶酶体中还含有一个透明的空泡。这些结构被命名为“金体”。使用MS 46(卡美卡)和Camebax(MBX)进行的微分析表明,这些晶体结构由与硫结合而非与磷结合的金组成。

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Subcellular localization of gold in suprarenal testicle and thyroid glands after injection of allochrysine in rats.给大鼠注射别黄嘌呤后,肾上腺、睾丸和甲状腺中金的亚细胞定位。
Cell Mol Biol (Noisy-le-grand). 1994 Jun;40(4):483-7.
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