埃克大鼠模型中的一种新型癌症易感性综合征。
A novel cancer predisposition syndrome in the Eker rat model.
作者信息
Hino O, Mitani H, Katsuyama H, Kubo Y
机构信息
Department of Experimental Pathology, Cancer Institute, Tokyo, Japan.
出版信息
Cancer Lett. 1994 Aug 15;83(1-2):117-21. doi: 10.1016/0304-3835(94)90307-7.
Hereditary renal carcinomas (RCs) develop in virtually all Eker rats by the age of one year. Investigation of extrarenal primary tumors occurring in Eker rats late in life (at 2 years) additionally revealed pituitary adenomas (17/31 = 54.8% (carrier) vs 7/32 = 21.9% (non-carrier siblings of affected animals), P < 0.01), sarcomas of the spleen (21/31 = 67.7% vs. 0/32 = 0%, P < 0.001) and sarcomas (of probable stromal origin) of the uterus (8/17 = 47.1% vs. 0/15 = 0%, P < 0.01). Thus, the Eker rat might provide a novel animal model of cancer predisposition syndromes.
几乎所有埃克大鼠在一岁时都会发生遗传性肾癌（RCs）。对埃克大鼠晚年（2岁时）出现的肾外原发性肿瘤的调查还发现了垂体腺瘤（17/31 = 54.8%（携带者） vs 7/32 = 21.9%（患病动物的非携带者同胞），P < 0.01）、脾脏肉瘤（21/31 = 67.7% vs. 0/32 = 0%，P < 0.001）和子宫肉瘤（可能起源于基质）（8/17 = 47.1% vs. 0/15 = 0%，P < 0.01）。因此，埃克大鼠可能为癌症易感性综合征提供一种新的动物模型。
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