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三尖杉属:高三尖杉酯碱及相关抗癌生物碱的来源。

The genus Cephalotaxus: source of homoharringtonine and related anticancer alkaloids.

作者信息

Smith C R, Powell R G, Mikolajczak K L

出版信息

Cancer Treat Rep. 1976 Aug;60(8):1157-70.

PMID:791485
Abstract

Various phases of research on Ciphalotaxus alkaloids are summarized, including their discovery, nature of antitumor activity, isolation, structural characterization, synthesis, biogenesis, and mechanism of physiologic action.

摘要

对三尖杉生物碱的各个研究阶段进行了总结,包括它们的发现、抗肿瘤活性的性质、分离、结构表征、合成、生物合成以及生理作用机制。

相似文献

1
The genus Cephalotaxus: source of homoharringtonine and related anticancer alkaloids.三尖杉属:高三尖杉酯碱及相关抗癌生物碱的来源。
Cancer Treat Rep. 1976 Aug;60(8):1157-70.
2
[Chemical, pharmacological and clinical studies on the antitumor active principle of Cephalotaxus hainanensis Li (author's transl)].海南粗榧抗肿瘤有效成分的化学、药理及临床研究(作者译)
Zhonghua Zhong Liu Za Zhi. 1979;1(3):176-82.
3
[Studies on the alkaloids of Cephalotaxus. IX. Semi-synthesis of cephalotaxine esters and their anti-leukemic activity].[三尖杉生物碱的研究。IX. 三尖杉酯碱的半合成及其抗白血病活性]
Yao Xue Xue Bao. 1992;27(3):178-84.
4
Synthesis of cephalotaxine esters and correlation of their structures with antitumor activity.三尖杉酯碱酯的合成及其结构与抗肿瘤活性的相关性。
J Med Chem. 1977 Mar;20(3):328-32. doi: 10.1021/jm00213a002.
5
Cephalotaxus Alkaloids.三尖杉生物碱
Alkaloids Chem Biol. 2017;78:205-352. doi: 10.1016/bs.alkal.2017.07.001. Epub 2017 Aug 16.
6
Indicine-N-oxide: the antitumor principle of Heliotropium indicum.
Lloydia. 1976 Mar-Jun;39(2-3):125-8.
7
[Antitumor activities and mechanisms of action of harringtonine and homoharringtonine].[三尖杉酯碱和高三尖杉酯碱的抗肿瘤活性及作用机制]
Gan To Kagaku Ryoho. 1984 Nov;11(11):2393-9.
8
[Isolation and identification of the antitumor agent--hainanolide from Cephalotaxus fortunei (author's transl)].
Yao Xue Xue Bao. 1981 Mar;16(3):233-4.
9
Antitumor activities of harringtonine and homoharringtonine, cephalotaxus alkaloids which are active principles from plant by intraperitoneal and oral administration.三尖杉酯碱和高三尖杉酯碱(从植物中提取的活性成分——三尖杉生物碱)通过腹腔注射和口服给药的抗肿瘤活性。
J Pharmacobiodyn. 1982 Oct;5(10):841-7. doi: 10.1248/bpb1978.5.841.
10
Pharmacology of antitumor agents from higher plants.高等植物抗肿瘤药物的药理学
Cancer Treat Rep. 1976 Aug;60(8):1127-39.

引用本文的文献

1
Homoharringtonine: mechanisms, clinical applications and research progress.高三尖杉酯碱:作用机制、临床应用及研究进展
Front Oncol. 2025 Jan 30;15:1522273. doi: 10.3389/fonc.2025.1522273. eCollection 2025.
2
Dose-enhanced combined priming regimens for refractory acute myeloid leukemia and middle-and-high-risk myelodysplastic syndrome: a single-center, retrospective cohort study.难治性急性髓系白血病及中高危骨髓增生异常综合征的剂量强化联合启动方案:一项单中心回顾性队列研究
Onco Targets Ther. 2016 Jun 20;9:3661-9. doi: 10.2147/OTT.S96427. eCollection 2016.
3
Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue.
通过靶向磷酸化的丝氨酸209残基实现小分子诱导磷酸化真核翻译起始因子4E(phospho-eIF4E)的SUMO化和降解。
Oncotarget. 2015 Jun 20;6(17):15111-21. doi: 10.18632/oncotarget.3615.
4
Low dose of homoharringtonine and cytarabine combined with granulocyte colony-stimulating factor priming on the outcome of relapsed or refractory acute myeloid leukemia.低剂量高三尖杉酯碱和阿糖胞苷联合粒细胞集落刺激因子预处理对复发或难治性急性髓系白血病的疗效。
J Cancer Res Clin Oncol. 2011 Jun;137(6):997-1003. doi: 10.1007/s00432-010-0947-z. Epub 2010 Dec 9.
5
Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemia.高三尖杉酯碱降低慢性淋巴细胞白血病中 Mcl-1 的表达并诱导其凋亡。
Blood. 2011 Jan 6;117(1):156-64. doi: 10.1182/blood-2010-01-262808. Epub 2010 Oct 22.
6
Effect of homoharringtonine on the viability of murine leukemia P388 cells resistant to either adriamycin, vincristine, or 1-beta-D-arabinofuranosylcytosine.高三尖杉酯碱对耐阿霉素、长春新碱或1-β-D-阿拉伯呋喃糖基胞嘧啶的小鼠白血病P388细胞活力的影响。
Cancer Chemother Pharmacol. 1989;23(3):145-50. doi: 10.1007/BF00267945.